Reno-protective Effect of Methanolic Extract of Stevia Rebaudiana Bertoni and Bioactive Phenolic Compounds In Type-1- Diabetes

Document Type : Original Article

Authors

1 Department of Organic Chemistry, Faculty of Science, Zagazig University, Zagazig, Egypt

2 Department of Phytochemistry and Plant Systematics ,National Research Center , Egypt

3 Department of Physiology, Faculty of Medicine, Mansoura University, Mansoura, Egypt

4 Department of Biology, Faculty of Science, JazanUniversity, Jazan, Saudi Arabia

Abstract

The aim of this study is to evaluate the reno-protective effect of the defatted methanolic extract of Stevia rebaudiana which showed the highest improvement of renal parameters, as it reduced the protein urea, blood urea nitrogen and blood creatinine and nephroprotective properties with reduced hyperglycemia complications through protection of renal tissues in type-1 diabetes. Also, identification of bioactive phenolic compounds of defatted methanolic extract using HPLC analysis, demonstrate the presence of diterpene glycosides, stevioside, rebaudioside A and chlorogenic acid

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History

  • Receive Date: 15 April 2018
  • Revise Date: 07 May 2018
  • Accept Date: 13 May 2018

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