Synthesis, Characterization and Antimicrobial Activity of Novel Pyrrolidine-3-Carbonitrile Derivatives,

Document Type : Original Article

Authors

1 Department of Organometallic and Organometalloid Chemistry, National Research Centre, 33 El-Bohouth St.(former EL Tahrir st.), P.O. 12622, Dokki, Giza, Egypt

2 Microbial Chemistry Department, National Research Centre, 33 El-Bohouth St.(former EL Tahrir st.), P.O. 12622, Dokki, Giza, Egypt

Abstract

Newly synthesized pyrrolidine-3-carbonitrile derivatives were evaluated as antimicrobial activity. The structures of these derivatives were derived from reactions of 1-(4-methoxyphenyl)-4-oxopyrrolidine-3-carbonitrile with stabilized phosphorus ylides, Wittig-Horner reagents, trialkylphosphites, as well as tris(dialkylamino)phosphines

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History

  • Receive Date: 06 March 2018
  • Revise Date: 11 April 2018
  • Accept Date: 12 April 2018

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