Antidiabetic, Antihyperlipidemic and Antioxidant Activities of Acacia albida in Streptozotocin-induced Diabetes in Rats and its Metabolites

Garra, Ahmed H.; Eltomy, Sayed A.; Aarrag, Abdel-razik H.; Ahmed, Nadia M.

doi:10.21608/ejchem.2019.18863.2160

Antidiabetic, Antihyperlipidemic and Antioxidant Activities of Acacia albida in Streptozotocin-induced Diabetes in Rats and its Metabolites

Document Type : Original Article

Authors

¹ Chemistry of Natural compounds, National Research Center, 12622 Dokki, Cairo, Egypt

² National Research center Tanning lab.

³ Pathology and Medical, National Research Center

⁴ 4Biochemistry Departments, National Research Center

10.21608/ejchem.2019.18863.2160

Abstract

The particular purpose of this research was to assess the antidiabetic, antihyperlipidemic and antioxidant activities of Acacia albdia methanol extract. In addition, a phytochemical study for A. albdia has been performed. Isolation and identification of pure compounds were carried out by different chromatographic and spectroscopic techniques. Quercetin, kaempferol and their glycosides have been isolated from A. albida leaves. Structures of the isolated compounds have been estimated by 1D/2D 1H/13C-NMR spectroscopy. Methanolic extract of the leaves of A. albida improved the diabetes status, and it showed antidiabetic, antihyperlipidimic and antioxidant effects. These findings suggest that A. albida leaves may be used as hypolipidemic and normo-glycemic agents, additionally; A. albida is a rich source of phenolic compounds

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