Lipid Biochemistry as a Mirror Image of SARS-CoV-2 Prognosis

Document Type : Review Articles

Authors

1 Cairo University

2 Undergraduate student, Faculty of Medicine, Cairo University

Abstract

The Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has resulted in over one hundred million infections and over three million deaths worldwide. Understanding the pathogenesis is critical for the prognostic and therapeutic implications. Viral infections are well-identified to change the lipid profiles and the metabolism of their host cells. Since lipids have various metabolic functions, investigating lipid profile changes in SARS-CoV-2 is an inevitable stage as a trial to attain better strategies for therapy, together with potential prognostic factors in the disease course. Numerous reports have investigated the alterations in lipid profiles that are present during SARS-CoV-2 infection. The most frequently observed alterations are reductions in levels of serum total cholesterol (TC), (low-density lipoproteins) LDL, (high-density lipoproteins) HDL, Apoprotein A1 and elevations of levels of serum Lipoprotein A, triglycerides (TG) and TG/HDL ratio. Viral replications significantly alter the host cell's lipid metabolism program and overuse the cell lipids for their replications. Lower levels of TC, HDL, and LDL are linked to greater severity and mortality rates and higher levels of inflammatory markers. Previous reports proposed that omega-3 derivatives may help modulate the cytokine storm. Besides, statins are shown to be valuable when used after SARS-CoV-2 diagnosis

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History

  • Receive Date: 07 November 2023
  • Revise Date: 29 December 2023
  • Accept Date: 30 January 2024

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