Investigation of A Novel Antimicrobial Chitosan Packaging Hydrogel Film Based On Azoloazine Derivative

Document Type : Original Article

Authors

1 Packaging Materials Department, National Research Centre, 33 El Bohouth St. (former El Tahrirst.), Dokki, Giza, Egypt, P.O. 12622 Tel/ Fax, (202) 33322418 (202) 33370931

2 Chemistry of Natural and Microbial Products Department, National Research Centre, 33 El Bohouth St. (former El Tahrirst.), Dokki, Giza, Egypt, P.O. 12622 Tel/ Fax, (202) 33322418 (202) 33370931

3 Microbial Chemistry Department, National Research Centre, 33 El Bohouth St. (former El Tahrirst.), Dokki, Giza, Egypt, P.O. 12622 Tel/ Fax, (202) 33322418 (202) 33370931

4 Pre-treatment and Finishing of Cellulose-based TextilesDepartment National Research Centre, 33 El Bohouth St. (former El Tahrirst.), Dokki, Giza, Egypt, P.O. 12622 Tel/ Fax, (202) 33322418 (202) 33370931

Abstract

The purpose of this work is to develop a novel active packaging chitosan hydrogel film (H17@CH) containing azoloazine derivatives as a novel antibacterial agent (11-(2-chlorobenzylidene)-6-(2-chlorophenyl)-6a, 7, 8, 9, 10, and 11-hexahydro-6H-benzo[b] (cyclohepta[e][1,4]thiazepine). The H17 revealed significant cell viability. H17 was added to chitosan in various quantities (100, 130, and 150µg). Significant cell viability was found in the H17. Chitosan was mixed with H17 in varying concentrations (100, 130, and 150 µg). Escherichia coli, Staphylococcus aureus, and Candida albicans are all susceptible to the antibacterial effects of the films. The films were evaluated using ATR-IR, XRD, XPS spectroscopy, and SEM-EDS. The maximum swelling ratio was 69.413.9 g/g for H17(100)@CH. The H17(150)@CH film had the lowest WVP at 15.601.52 g.mm. kPa-1.h-1.m-2. Guggenheim-Anderson-de Boer, Peleg, and Smith were utilized to model the water vapor adsorption isotherms. All of the models were perfectly fitted

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