Antitumor Potential and Possible Targets of Phenothiazine Derivatives: A Recent Review

Document Type : Review Articles

Authors

1 Labelled Compounds Department, Hot Lab Center, Egyptian Atomic Energy Authority

2 Pharmaceutical Chemistry department Faculty of pharmacy Helwan University Cairo Egypt

3 Helwan University

4 1Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Helwan University, P.O. Box 11795, Cairo, Egypt

Abstract

The unique chemical characteristics of the phenothiazine ring system have been a major driving force for the development of various phenothiazine-based compounds with a huge spectrum of industrial and biological significance. Literature is ever continuously growing discussing the different roles and synthetic routes of phenothiazines. A huge body of novel and repurposed phenothiazines have been reported to have antitumor action. Unfortunately, only few reports discuss the proper mechanism of such action. In this review, a comprehensive overview of the identified targets and/or mechanism of action of recently reported antitumor phenothiazine derivatives are reviewed.

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Egyptian Journal of Chemistry
Volume 66, Issue 13 - Serial Number 13
Special Issue: Applied Chemistry for Greener Life and Sustainability
December 2023
Pages 1001-1014

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History

  • Receive Date: 11 March 2023
  • Revise Date: 30 April 2023
  • Accept Date: 03 May 2023

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