Comparative toxicological studies of some food additives on foetal development in rats

Document Type : Original Article

Authors

1 Pharmacology department, medical division, national research centre

2 National Research Center

3 department of nutrition and food science, NRC, Egypt

Abstract

This study aimed to compare the impact of some common food additives (MSG, ACK, BHA and BHT) on fetal development. To do this, forty female albino rats weighing approximately 200g were examined to determine their estrous period and then paired with appropriate fertile males. The effects of these food additives on fetal development were then monitored throughout the remainder of the pregnancy period. On the sixth day of pregnancy, the pregnant rats were divided into five different groups: Group A (control) received saline, while Groups B-E received MSG, ACK, BHA and BHT respectively in doses of 3, 15, 25 and 14 mg kg-1 day-1. Upon morphological, visceral and skeletal examination of the fetuses, it was concluded that the food additives had a significant negative impact on fetal development. Therefore, it is advised that consumers should avoid consuming food additives during this period of gestation.

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History

  • Receive Date: 31 January 2023
  • Revise Date: 09 March 2023
  • Accept Date: 14 March 2023

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