Document Type : Original Article
Authors
1
Department of Chemistry, Faculty of Science, sohag Univesity Sohag,82524,Egypt.
2
Department of Analytical chemistry, Faculty of Pharmacy, sohagUnivesity, Sohag, 82524,Egypt
3
Biochemistry Department, Faculty of Science, King Abdulaziz University, Jeddah 2155, Saudi Arabia
4
Department of Biology, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia
5
Yousef Abdul Latif Jameel Scientific Chair of Prophetic Medicine Application, Faculty of Medicine, King Abdulaziz University, Jeddah 22254, Saudi Arabia
6
Faculty of Medicine, Assuit University, Assuit 98467,
Abstract
Background: Acrylamide was well known to induce oxidative stress with an impact on reproductive functions on both male and female. Taurine is a potent antioxidant. This study was conducted as a trail to abrogates acrylamide induced reproductive toxicity in female rats by administration of taurine. Animals were divided into 4 groups (N= 10); Control group kept on balanced diet and saline (9%), Acrylamide (AA) group received acrylamide in drinking water (20 mg/kg b.w.) for 21days and acrylamide + taurine (AA+TA) treated with taurine (50 mg/kg b.w.) after acrylamide intoxication for 21 days and taurine (TA) group received taurine (50 mg/kg b.w.). Hormonal, antioxidants and tumor markers (CA125 and CEA) were assayed and correlated with histological changes in ovarian tissue.
Results: Administration of acrylamide produced significant increase in serum levels of estradiol, LH, testosterone and in tumor markers CA125 and CEA. Whereas those of progesterone, FSH and total antioxidant capacity (TAC) were significantly reduced. Histological study showed that AA result in apparent regression of ovarian follicles and corpus luteum degeneration and cyst formation. Treatment with taurine restored altered ovarian histology and serological indices concomitantly towards normal levels.
In conclusion:
Results revealed that taurine is able to significantly alleviate the reproductive toxicity induced by AA in female rats via modulating oxidative stress based on decreasing total antioxidant altered and has potential inhibitory role on the activation of the AKT1siganlling pathway involved in ovarian cancer progression so, it could be a promising potent dietary supplementation utilized against chemical intoxication.
Keywords
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