Antimicrobial Benzofuran Derivatives and Chemosystematic Significance of Senecio glaucus L. (Asteraceae)

Document Type : Original Article

Authors

1 Department of Pharmacognosy, Faculty of Pharmacy, Sphinx University, Assiut, Egypt,

2 Department of Botany, Faculty of Science, Aswan University, Egypt,

3 Department of Biological Science, Molecular Biotechnology program, Field of Advanced Basic Sciences, Galala University, New Galala City, Egypt,

4 Department of Chemistry, Faculty of Science, Aswan University, Egypt

Abstract

Phytochemical investigation of methylenechloride/methanol (1:1) extract of the air-dried aerial parts of Senecio glaucus L. afforded three benzofuran derivatives (1-3); 1-(6-hydroxy-2-(prop-1-en-2-yl) benzofuran-5-yl) ethanone, 1-1'-(6-hydroxybenzofuran-2,5-diyl) diethanone, and 1-1'-(6-methoxybenzofuran-2,5-diyl) diethanone. The crude extract and isolated compounds (1-3) were screened against S. aureus and E. coli and also against C. albicans and A. flavus. Compound 1 and 2 were more potent than 3 against S. aureus and E. coli, however, the crude extract and isolated compounds (1-3) showed weak antifungal activity against C. albicans and A. flavus. In addition, a biosynthetic pathway of isolated compounds (1-3) was proposed, as well as the chemotaxonomic significance of the reported benzofuran and furanoeremophilane derivatives from S. glaucus compared to those isolated from other Senecio species was also studied.

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History

  • Receive Date: 10 October 2022
  • Revise Date: 01 January 2023
  • Accept Date: 18 January 2023

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