Cytotoxic activity of some benzo[4,5]imidazo[1,2-a]pyrimidine derivatives against the human cancer cell lines HepG2 and MCF-7

Basyouni, Wahid; Abbas, Samir Youssef; El-bayouki, Khairy A.M; El-kady, Mohamed Y.; Abdelazeem, Nagwa M.; Dawood, Reham; Shemis, Mohamed A.

doi:10.21608/ejchem.2023.173878.7209

Cytotoxic activity of some benzo[4,5]imidazo[1,2-a]pyrimidine derivatives against the human cancer cell lines HepG2 and MCF-7

Document Type : Original Article

Authors

¹ National Research Centre

² Organometalic and Organometalliod Chemistry Department, National Research Centre

³ Organometallic chemistry Department, National research centre

⁴ Ain Shams university

⁵ Organometallic and Organometalloid Chemistry Department, National Research Centre, Cairo, Egypt.

⁶ Microbial Biotechnology Department, National Research Centre, Dokki, Cairo, Egypt

⁷ Biochemistry and Molecular Biology Department, Theodor Bilharz Research Institute,Cairo, Egypt.

10.21608/ejchem.2023.173878.7209

Abstract

Different benzo[4,5]imidazo[1,2-a]pyrimidine derivatives were synthesized in high purity and yields with short reaction times by the reaction of 2-aminobenzimidazole, aldehydes and active carbonyl compounds in the presence of Silica sulfuric acid/ethylene glycol (SSA/EG) as a catalyst. Cytotoxicity of the synthesized benzo[4,5]imidazo[1,2-a]pyrimidine derivatives 1-6 was carried out against the two human cancer cell lines, hepatocellular carcinoma (HepG2) and breast carcinoma (MCF-7) as well as Vero cells (normal cells).

Keywords