Nano metal complexes in cancer therapy, preparation, spectroscopic, characterization and anti-breast cancer activity of new metal complexes of alanine Schiff-base.

El Tabl, Abdou; Abd Wlwahed, Moshira; Abd-Elwareth, Manar; Faheem, Shimaa

doi:10.21608/ejchem.2021.52415.3082

Nano metal complexes in cancer therapy, preparation, spectroscopic, characterization and anti-breast cancer activity of new metal complexes of alanine Schiff-base.

Document Type : Original Article

Authors

¹ Department of Chemistry, Faculty of Science, El-Menoufia University, Shebin El -Kom, Egypt.

² Department of Pathology, Faculty of Medicine, El-Menoufia University, Shebin El-Kom, Egypt.

10.21608/ejchem.2021.52415.3082

Abstract

There are many properties of metal ions that were useful for solving basic problems in medicine, metal complexes with particular properties can be covalently affected to biological macromolecules. Mono Co(II), Ni(II) ,Cu(II) ,Zn(II) ,Mg(II) and binuclear Zn(II)/Cu(II) and Ni(II)/Cu(II) complexes of new Schiff-base derived from alanine amino acid ester have been synthesized and characterized. They were studied using elemental and spectral analysis such as IR,UV-VIS,1H-NMR mass spectroscopy as well as conductivity, magnetism, thermal analysis (DTA and TGA), electron microscope and ESR measurements. Conductance measurements of metal complexes indicated non electrolytic in nature. Elemental and spectral analysis confirmed distorted octahedral structural for all complexes. ESR spectra of complexes showed anisotropic or isotropic spectra with covalent bond character. Electron microscope data showed that, complexes with high biological activity were found in Nano form. The ligand and some of its complexes were studied against breast cancer (in vitro) and exhibited moderate to high activity compared to standard drug (doxorubicin). The order of activity was (doxorubicin)= ligand (1) > Ni(II)/Cu(II) complex (19) > Zn(II)/Cu(II) complex (20) > Zn(II) complex (18).

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