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Egyptian Journal of Chemistry
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Volume Volume 62 (2019)
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Chandra, S., Chaurasia, M., Tomar, D. (2019). BSA binding studies of Co(II), Ni(II) and Cu(II) metal complexes of Schiff base derived from 2-hydroxy-4-methoxybenzaldehyde and 2-amino-6-methylbenzothiazole. Egyptian Journal of Chemistry, 62(2), 73-80. doi: 10.21608/ejchem.2018.4907.1434
Sulekh Chandra; Madhuri Chaurasia; Deepak Tomar. "BSA binding studies of Co(II), Ni(II) and Cu(II) metal complexes of Schiff base derived from 2-hydroxy-4-methoxybenzaldehyde and 2-amino-6-methylbenzothiazole". Egyptian Journal of Chemistry, 62, 2, 2019, 73-80. doi: 10.21608/ejchem.2018.4907.1434
Chandra, S., Chaurasia, M., Tomar, D. (2019). 'BSA binding studies of Co(II), Ni(II) and Cu(II) metal complexes of Schiff base derived from 2-hydroxy-4-methoxybenzaldehyde and 2-amino-6-methylbenzothiazole', Egyptian Journal of Chemistry, 62(2), pp. 73-80. doi: 10.21608/ejchem.2018.4907.1434
Chandra, S., Chaurasia, M., Tomar, D. BSA binding studies of Co(II), Ni(II) and Cu(II) metal complexes of Schiff base derived from 2-hydroxy-4-methoxybenzaldehyde and 2-amino-6-methylbenzothiazole. Egyptian Journal of Chemistry, 2019; 62(2): 73-80. doi: 10.21608/ejchem.2018.4907.1434

BSA binding studies of Co(II), Ni(II) and Cu(II) metal complexes of Schiff base derived from 2-hydroxy-4-methoxybenzaldehyde and 2-amino-6-methylbenzothiazole

Article 14, Volume 62, Issue 2, February 2019, Page 73-80  XML
Document Type: Original Article
DOI: 10.21608/ejchem.2018.4907.1434
Authors
Sulekh Chandra email orcid 1; Madhuri Chaurasia2; Deepak Tomar2
1Department of Chemistry, Zakir Husain Delhi College, University of Delhi, New Delhi-110001, India
2Department of Chemistry, Zakir Husain Delhi College, University of Delhi, JLN-Marg, New Delhi-110002, India
Receive Date: 24 August 2018,  Revise Date: 17 September 2018,  Accept Date: 27 September 2018 
Abstract
The synthesis of Schiff base HL has been done by taking an equimolar ratio of 2-hydroxy-4-methoxybenzaldehyde and 2-amino-6-methylbenzothiazole. Ligand HL has been characterized by elemental analysis, IR, 1H NMR, 13C NMR and ESI-mass spectrometry. The metal complexes 1-6 have been synthesized by the reaction of ligand HL with hydrated Co(II), Ni(II) and Cu(II) chlorides in ethanol, in the ligand to metal molar ratio 1:1 and 2:1. The synthesized metal complexes 1-6 were characterized by elemental analysis, molar conductance, electronic spectra, IR, UV-visible and EPR spectra. TGA has been done to check the thermal stablity of ligand as well as metal complexes. Spectral data reveals that the ligand HL acts as uninegative bidentate for all metal complexes. The geometries of metal complexes 1-6 have been given on the basis of spectroscopic studies and optimized by density functional theory. The fluorescence techniques have been used to study the interactions of metal complexes towards bovine serum albumin (BSA). The results revealed that the fluorescence static quenching of BSA by metal complexes 1-6 and entropy driven hydrophobic interactions has been seen which could be useful for further drug design.
Keywords
Schiff Base; Metal complexes; TGA; BSA binding
Main Subjects
Inorganic chemistry
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