1.4-Arylation of β-(4-acetylaminobenzoyl)acrylic Acid with Activated Aromatic Hydrocarbons under Friedel-Crafts Conditions and Some Studies with the Products

Abstract

THE BEHAVIUOR of 3-(4-acetylaminobenzoyl) prop-2-enoic acid 1 with m-xylene and\or p-xylene under Friedel-Craft,s reaction conditions yielded 2- ( 2,4-Dimethyl and/or 2,5-dimethyl ) phenyl-3-(4-acetylaminobenzoyl)propanoic acids (2a,b) and thia-Micheal of acid 1 afforded 2- phenyl sulfanyl-3-(4-acetylamino benzoyl propanoic acid (3). Interaction of acids 2,3 with N2H4 , AC2O, NH2OH.HCl and PhNHNH2, yielded pyridazinone 4 , Furanone 5 1, 2oxazine 6 and 2-phenyl pyridazinone derivatives, respectively. Treatment of pyridazinone 4 with different interesting alkyl halides afforded the pyridazine derivatives 8 .

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History

  • Receive Date: 04 January 2011
  • Revise Date: 31 July 2011
  • Accept Date: 01 August 2011

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