THE COUPLING reaction of 2-diazo-3-cyano-4,5,6,7-tetrahydrobenzo [b] thiophene (2) with the 2-aminoprop-1-ene-1,1,3-tricarbonitrile (3) gave the hydrazone derivative (4). Compound 4 underwent ready cyclization to give the pyridazine derivative (5). The reaction of 4 with hydrazines gave pyrazole derivatives (6a,b). On the other hand, the reaction of 4 with active methylene reagents gave the pyridazine derivatives (7a,b). The latter products were cyclized into the pyrido [3,2-c] pyrimidine derivatives 8a and 8b, respectively. The reaction of 4 with phenylisothiocyanate gave the 1,2,4-triazine derivative (9). The antidepressant and sedative activities of the newly synthesized products were measured.
(2010). Synthesis and Evaluation of Antidepressant and Sedative Activities of Some Benzo[B] thiophenes. Egyptian Journal of Chemistry, 53(4), 515-526. doi: 10.21608/ejchem.2010.1246
MLA
. "Synthesis and Evaluation of Antidepressant and Sedative Activities of Some Benzo[B] thiophenes". Egyptian Journal of Chemistry, 53, 4, 2010, 515-526. doi: 10.21608/ejchem.2010.1246
HARVARD
(2010). 'Synthesis and Evaluation of Antidepressant and Sedative Activities of Some Benzo[B] thiophenes', Egyptian Journal of Chemistry, 53(4), pp. 515-526. doi: 10.21608/ejchem.2010.1246
VANCOUVER
Synthesis and Evaluation of Antidepressant and Sedative Activities of Some Benzo[B] thiophenes. Egyptian Journal of Chemistry, 2010; 53(4): 515-526. doi: 10.21608/ejchem.2010.1246
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