THREE analogs of Bradykinin, (Cys6,8) BK, (Cys2,5) BK and (Cys1,9) BK were synthesized by modified solid phase peptide synthesis with the application of microwave energy. The effect of the replacement of; Ser6 and Phe8 by Cys6,8, Pro2 and Phe5 by Cys2,5,and Arg1,9 by Cys1,9 on the biological activity of bradykinin was investigated. A continued work of a previously done study includes synthesis of three BK analogs, (Lys1) BK, (Lys9) BK and (Lys1, 9) BK, using the modified solid phase peptide synthesis with microwave energy. The six analogues have been tested in vitro for their effect on heart rate and in isolated organ for the arterial pressure of rats.
(2013). Solid Phase Peptide Synthesis of Some Analogs of Bradykinin Hormone Using Microwave Energy Application (part II). Egyptian Journal of Chemistry, 56(2), 141-153. doi: 10.21608/ejchem.2013.1104
MLA
. "Solid Phase Peptide Synthesis of Some Analogs of Bradykinin Hormone Using Microwave Energy Application (part II)". Egyptian Journal of Chemistry, 56, 2, 2013, 141-153. doi: 10.21608/ejchem.2013.1104
HARVARD
(2013). 'Solid Phase Peptide Synthesis of Some Analogs of Bradykinin Hormone Using Microwave Energy Application (part II)', Egyptian Journal of Chemistry, 56(2), pp. 141-153. doi: 10.21608/ejchem.2013.1104
VANCOUVER
Solid Phase Peptide Synthesis of Some Analogs of Bradykinin Hormone Using Microwave Energy Application (part II). Egyptian Journal of Chemistry, 2013; 56(2): 141-153. doi: 10.21608/ejchem.2013.1104
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