Efficient Heterogeneous Catalytic One-Pot, Three Component Synthesis of γ-Hydroxy-β-Ketoamides

Abstract

TETRACHLOROSILANE/zinc chloride is used as an efficient heterogeneous reagent to promote a one-pot, three component synthesis of γ-Hydroxy-β-ketoamides by the reaction of dimedone, as a 1,3-diketone with various aromatic aldehydes and various nitriles, in dichloromethane at ambient temperature

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