National Information and Documentation Centre (NIDOC), Academy of Scientific Research and Technology, ASRT
Egyptian Journal of Chemistry
0449-2285
2357-0245
55
1
2012
02
28
Utility of 4-(4-Bromophenyl)-4-oxo-but-2-enoic Acid in Synthesis of Some Important Heterocyclic Compounds
1
13
EN
10.21608/ejchem.2012.1127
THE PRESENT work deals with the generation and synthesis of different heterocycles
<em><span style="font-family: Times New Roman; font-size: xx-small;"><span style="font-family: Times New Roman; font-size: xx-small;">via </span></span></em><span style="font-family: Times New Roman; font-size: xx-small;"><span style="font-family: Times New Roman; font-size: xx-small;">the treatment of 3-(4-bromobenzoyl) prop-2-enoic acid (1) with thiourea, ethylcyanoacetate malononitrile & acetylacetone in presence of amm.acetate and / or piperidine , 2-amino-5-phthalimidomethy l1,3,4-thiadiazole, methyl thioglycolate 4-bromoaniline and ethylacetoacetate to afford Michael and aza-Michael adduct that cyclized by hydroxyl amine and hydrazine hydrate, respectively. Additionally, utility of 2-(2-amino-5-phthalimidomethyl 1,3,4-thiadiazol-2-yl)-4-(4-bromophenyl)-4-oxo-butanoic acid (4) as a key starting material to synthesize some important heterocycles include fused oxoimidazolo [2,3-b]-1,3,4-thiadiazole.</span></span>
4-Bromophenyl-4-oxo-2-butenoic acid,Pyridine,Pyrimidine,Phthalazinhydrazone,Benzisoxazolone,Phthalimide,Thiadiazole imidazolothiadiazole and Pyridazinone
https://ejchem.journals.ekb.eg/article_1127.html
https://ejchem.journals.ekb.eg/article_1127_60147b2643d02090412cdfd0b465ddf3.pdf
National Information and Documentation Centre (NIDOC), Academy of Scientific Research and Technology, ASRT
Egyptian Journal of Chemistry
0449-2285
2357-0245
55
1
2012
02
28
Synthesis, Characterization, Spectrofluorometric and Antibacterial Activity Studies of Moxifloxacin- Zirconium Complex
15
31
EN
10.21608/ejchem.2012.1128
<br /> <span style="font-size: xx-small;">Smagnetic resonance in combination with thermal analysis measurements were used to verify and describe the physicochemical properties of the synthesized moxifloxacin (MOX) Zirconium (IV) metal complex. The spectroscopic and elemental analysis data support the formation of the complex with the formula C</span><span style="font-size: xx-small;">21</span><span style="font-size: xx-small;">H</span><span style="font-size: xx-small;">23</span><span style="font-size: xx-small;">FN</span><span style="font-size: xx-small;">3</span><span style="font-size: xx-small;">O</span><span style="font-size: xx-small;">4</span><span style="font-size: xx-small;">Zr(H</span><span style="font-size: xx-small;">2</span><span style="font-size: xx-small;">O)</span><span style="font-size: xx-small;">2</span><span style="font-size: xx-small;">.0.5H</span><span style="font-size: xx-small;">2</span><span style="font-size: xx-small;">O. Results revealed that complexation between Zirconium (IV) and moxifloxacin exhibited significant increase in antibacterial activity especially against Gram negative organisms. </span><br /> In addition, a simple, rapid, reliable, and sensitive spectrofluorometric method is developed for the determination of MOX. The method depends on the chelation of MOX with zirconium (IV) to produce fluorescent chelate (MOX/ Zr). Different factors affecting the relative fluorescence intensity of the resulting chelate were studied and optimized. The relationship between the concentration and relative fluorescence intensity was rectilinear in the range of 0.1–4 μg/ml. The limits of detection and quantitation are 0.06 and 0.11 μg/ ml, respectively.<br /> At the optimum reaction conditions, the drug–metal chelate showed excitation maximum at 333 nm and emission maxima at 485nm. The developed method was applied successfully for the determination of the studied drug in its pharmaceutical dosage forms with a good precision and accuracy.
Moxifloxacin,Metal complexation,Spectrofluorometric,Thermal analysis and Antibacterial
https://ejchem.journals.ekb.eg/article_1128.html
https://ejchem.journals.ekb.eg/article_1128_6f0eed43aa860f36287f7ae89ab11245.pdf
National Information and Documentation Centre (NIDOC), Academy of Scientific Research and Technology, ASRT
Egyptian Journal of Chemistry
0449-2285
2357-0245
55
1
2012
02
28
Synthesis of Core/Shell Nano Finish for Antimicrobial Cotton Fabrics
33
56
EN
10.21608/ejchem.2012.1130
<br /> <span style="font-size: xx-small;">SILVER loaded chitosan /methoxy polyethylene glycol chloro ……triazine (Ag/chit-MPEGT) core/shell nano particles were synthesized as a durable finish for cotton fabrics. Ag/chit-MPEGT was firstly synthesized by reaction of silver loaded chitosan (Ag-chit) with methoxy polyethylene glycol dichlorotriazine. The latter was prepared by reaction of MPEG with 2,4,6-trichloro-s-triazine in acetone and sodium carbonate. Silver loaded chitosan(Ag/chit) nanoparticles were prepared by Ionotropic gelatin method. The resulting Ag/chit-MPEGT core/shell nano-particles were characterized by IR-spectra, </span><span style="font-size: xx-small;">1</span><span style="font-size: xx-small;">H NMR spectroscopy, X-ray diffraction (XRD), transmission electron microscopy (TEM) and elemental spectroscopy imaging (ESI). The cotton fabric is treated with the prepared core/shell nanoparticles using the conventional and convenient pad-dry-cure techniques to impart the durable antimicrobial properties. Citric acid was used as a crosslinking agent to improve the morphology, the crease resistance and the durable press finishing of the treated fabric. The latter was tested for the fabric surface morphology, crease resistance, break tensile strength, elongation–at-break, air permeability and antimicrobial activity. </span>
https://ejchem.journals.ekb.eg/article_1130.html
https://ejchem.journals.ekb.eg/article_1130_d1030c34793bd2c93e4f07883022bffc.pdf
National Information and Documentation Centre (NIDOC), Academy of Scientific Research and Technology, ASRT
Egyptian Journal of Chemistry
0449-2285
2357-0245
55
1
2012
02
28
New Palladium (II) Complexes Bearing Benzopyran Derivative Ligands: Synthesis and Characterization
57
72
EN
10.21608/ejchem.2012.1131
<br /> <span style="font-size: small;">PALLADIUM complexes of (4-methoxyphenyl benzopyran, </span><br /> 4- fluorophenyl benzopyran and 4-(2<br /> <strong><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">-</span></span></strong><span style="font-size: small;">chloro-5-nitro) phenyl benzopyran ligands) have been synthesized and characterized using different tools such as IR, UV/Vis, </span><span style="font-size: xx-small;">1</span><span style="font-size: small;">H-NMR, elemental analysis, thermal analysis, and mass spectroscopy. The mode of binding Pd (II) ion with the ligands shows that the Pd (II) ion binds with the ligands through the amino group nitrogen atom and cyanide group nitrogen atom of the ligands which revealed a square-planar coordination geometry at the metal center [Pd L</span><span style="font-size: xx-small;">1</span><span style="font-size: small;">.2Cl] 0.5H</span><span style="font-size: xx-small;">2</span><span style="font-size: small;">O,[Pd L</span><span style="font-size: xx-small;">2 </span><span style="font-size: small;">.2Cl] 1.5H</span><span style="font-size: xx-small;">2</span><span style="font-size: small;">O and [Pd L</span><span style="font-size: xx-small;">3 </span><span style="font-size: small;">.2Cl]. </span>
https://ejchem.journals.ekb.eg/article_1131.html
https://ejchem.journals.ekb.eg/article_1131_06178b030d3301aeb342e042f8746248.pdf
National Information and Documentation Centre (NIDOC), Academy of Scientific Research and Technology, ASRT
Egyptian Journal of Chemistry
0449-2285
2357-0245
55
1
2012
02
28
Effects of River Inputs on Mediterranean Coastal Shore Line in front of Damietta Estuary
73
84
EN
10.21608/ejchem.2012.1132
<br /> <span style="font-size: xx-small;">THE WATER quality characteristics and some heavy metals cations (Fe</span><span style="font-size: xx-small;">2+</span><span style="font-size: xx-small;">, Mn</span><span style="font-size: xx-small;">2+</span><span style="font-size: xx-small;">, Zn</span><span style="font-size: xx-small;">2+</span><span style="font-size: xx-small;">, Cu</span><span style="font-size: xx-small;">2+ </span><span style="font-size: xx-small;">and Pb</span><span style="font-size: xx-small;">2+</span><span style="font-size: xx-small;">) of Damietta estuary and in front of Mediterranean coastal shoreline were evaluated through four successive cruises (February 2008 to November 2008). Twelve sites were selected from the two sectors. The results obtained showed that serious deterioration of quality of water at Damietta estuary compared with Mediterranean shoreline. The concentrations of major cations and anions increased progressively while moving away from Damietta Estuary to the sea which reflect the effect of seawater intrusion into estuary. Contrarily, nutrient salts values in the estuary showed elevated values due to heavily polluted waste water poured into estuary where the nutrient salts content of the Mediterranean Sea water depend on its levels in Damietta Estuary. The distribution order of heavy metals concentrations in water samples was Fe > Mn > Pb > Zn > Cu > Cd. </span>
https://ejchem.journals.ekb.eg/article_1132.html
https://ejchem.journals.ekb.eg/article_1132_b76fd6834d8279b9b8bedf7a055c52f5.pdf
National Information and Documentation Centre (NIDOC), Academy of Scientific Research and Technology, ASRT
Egyptian Journal of Chemistry
0449-2285
2357-0245
55
1
2012
02
28
Fabrication and Characterization of Nano-Hydroxyapatite\ Chitosan Biocomposites with and without Citric Acid Addition
85
97
EN
10.21608/ejchem.2012.1134
<br /> <span style="font-size: xx-small;">BIOCOMPOSITES composed of carbonated apatite and chitosan in ….. the presence or absence of citric acid were fabricated through a co-precipitation method. The prepared biocomposites were characterized by Fourier transformed infrared spectroscopy (FT-IR), X- ray diffraction (XRD), Thermo gravimetric analysis (TGA), Transmission electron microscopy (TEM), and Scanning electron microscopy (SEM). The results proved that the presence of citric acid in the composite accelerated HA formation and reduced its particle size. Also, the compressive strength increased for HA/chitosan composite compared to HA alone and more increased with addition of citric acid which enhanced the binding strength between HA particles. The HA/chitosan composite with ratio 70% HA and 30% chitosan, especially with citric acid, may be promising for bone grafting and bone tissue engineering applications. </span>
Apatite,Chitosan,Biocomposites,Citric acid and TEM
https://ejchem.journals.ekb.eg/article_1134.html
https://ejchem.journals.ekb.eg/article_1134_714c43f6a08567098e45fdc47118da70.pdf
National Information and Documentation Centre (NIDOC), Academy of Scientific Research and Technology, ASRT
Egyptian Journal of Chemistry
0449-2285
2357-0245
55
1
2012
02
28
Synthesis of Some Heterocyclic Molecuoles from New Benzoxazinones and Quinazolinones
99
110
EN
10.21608/ejchem.2012.1135
THE BENZOXAXAZINONE 3 was prepared and treated with
<span style="color: #ffffff; font-family: Times New Roman; font-size: xx-small;"><span style="color: #ffffff; font-family: Times New Roman; font-size: xx-small;"><span style="color: #ffffff; font-family: Times New Roman; font-size: xx-small;">…... </span></span></span><span style="font-family: Times New Roman; font-size: xx-small;"><span style="font-family: Times New Roman; font-size: xx-small;">hydrazine hydrate, hydroxylamine hydrochloride, and o-phenylenediamine to give different quinazolinones 4,5 and benzoimidazoles 6, 7, respectively.Product 4 reacted with different </span></span><span style="font-family: Times New Roman; font-size: xx-small;"><span style="font-family: Times New Roman; font-size: xx-small;">aldehydes forming different Schiff’s </span></span><span style="font-family: Times New Roman; font-size: xx-small;"><span style="font-family: Times New Roman; font-size: xx-small;">basses 9,10a - e. Also, it reacted with different Grignard reagents giving alcohols(11a,b) and ketones 11c,d, according to the bulkiness of the reagent. Finally, dibromo, monobromoamino and diaminoquinazolinones (12,13 a-d) & (14 a-d) were prepared upon addition of bromine to 4, followed by reacting different amines according to their molar ratios. Some benzoxazinone, and quinazolinone derivatives were tested for their antifungal and antibacterial activities and gave promising results.</span></span>
Quinazolinones,Benzoxazinones and Schiff’s base
https://ejchem.journals.ekb.eg/article_1135.html
https://ejchem.journals.ekb.eg/article_1135_3a1c22d9083ae199826b5b07bd7dc48d.pdf