eng
National Information and Documentation Centre (NIDOC), Academy of Scientific Research and Technology, ASRT
Egyptian Journal of Chemistry
0449-2285
2357-0245
2011-02-28
54
1
1
15
10.21608/ejchem.2011.1376
1376
Synthesis and Biological Activity of Some New Substituted Quinazolin-4(3H)-Ones
3- (4-AMINOPHENYL)-2-benzyl-4-oxo-3,4-dihydroquinazoline 1a and 3 - (4 - aminophenyl) - 2 - benzyl - 6 - bromo - 4 - oxo -3, 4 dihydroquinazoline 1b were prepared and diazotized by nitrous acid to give ″2a, b″. The diazonium chloride derivatives were converted to the corresponding 3-arylhydrazono derivatives on treatment with active methylene compounds namely acetylacetone, ethyl acetoacetate and/or ethyl cyanoacetate. The hydrazono derivatives were converted to the corresponding pyrimidino derivatives ″6a-f″, pyrazolo derivatives ″7a-d″ and pyrazoline derivatives ″8a-d″ and ″9a-f″ in order to study their antimicrobial activity. A significant level of activity of the new products was observed.
https://ejchem.journals.ekb.eg/article_1376_9db1210aa9948ab7b956306227d1a013.pdf
2- Benzyl - 4(3H) quinazolinone - 4 - (3H) - one
6-Bromo derivative
Aryl hydrazones
β-Diketones and Biological activity
eng
National Information and Documentation Centre (NIDOC), Academy of Scientific Research and Technology, ASRT
Egyptian Journal of Chemistry
0449-2285
2357-0245
2011-02-28
54
1
17
34
10.21608/ejchem.2011.1377
1377
Behaviour of 4,6-Diaryl-2(1H) pyrimidine-2-thiones Towards Some Electrophiles and Nucleophiles
4,6-DIARYl-1,2-dihydro-2(1H)-pyrimidine-2-thiones (1a,b) were ….used for the synthesis of several new pyrimidine derivatives. They were further subjected to hetero ring anellation affording isoxazolo [4,5-d] thiazolo [2,3-a] pyrimidine (5,6) and isoxazolo [4,5-d] thiazino [2,3-a] pyrimidines (11,12) . Biological evaluation of some of the prepared compounds revealed promising antimicrobial activity.
https://ejchem.journals.ekb.eg/article_1377_e672936bf842391e1b3deaf008ac9d4a.pdf
Pyrimidinethione
Pyrimidothiazine
Thiazolopyrimidine and Antimicrobial activity
eng
National Information and Documentation Centre (NIDOC), Academy of Scientific Research and Technology, ASRT
Egyptian Journal of Chemistry
0449-2285
2357-0245
2011-02-28
54
1
35
54
10.21608/ejchem.2011.1378
1378
Chemical Polymerization of Diphenylamine and Characterization of the Obtained Polymer
THE CHEMICAL polymerization of diphenylamine in DMF/water (50% v/v) using sodium dichromate as oxidant and HCl as dopant is performed. The effect of monomer, oxidant, HCl concentration and temperature on both initial and overall reaction rates is investigated. The data show that both the initial and overall reaction rates increase with the increasing of monomer, oxidant and HCl concentrations in the concentration range of study. Also, both the initial and overall reaction rates increase with increasing temperature. The reaction rate law is found to be:
R i = k2[monomer]0.723[oxidant]0.854[HCl]0.641
The apparent activation energy Ea is found to be 15.299 kJ/mol. Also, H* and S*, were calculated and found to be 12.67 kJ/mol and -90.184 J/mol.K, respectively.The obtained polymer sample prepared at the optimum conditions was characterized by IR, 1HMMR, TGA, DTA and electron microscopy. Also, elemental analysis was carried out to confirm the suggested structure of obtained polymer. The mechanism of the polymerization reaction was discussed.
https://ejchem.journals.ekb.eg/article_1378_4030c2b00b32f35270174f9c53d36590.pdf
Chemical polymerization
Initial and overall reaction rate
Monomer concentration
Oxidant concentration
Apparent activation energy and Characterization
eng
National Information and Documentation Centre (NIDOC), Academy of Scientific Research and Technology, ASRT
Egyptian Journal of Chemistry
0449-2285
2357-0245
2011-02-28
54
1
55
68
10.21608/ejchem.2011.1379
1379
Comparative Study on the Effect of Support for Nanonickel Catalyst in Reduction of Nitrophenols
THE CATALYTIC reduction of para- and ortho- nitrophenols to the corresponding aminophenols was investigated over Ni/TiO 2 catalysts prepared by reduction method. Hydrazine hydrate in the presence of nickel ions supported on TiO2 was used in the preparation of nanonickel catalyst over rutile and anatase. Further decomposition of the hydrazine hydrate on the nickel atoms surfaces yields nascent hydrogen atoms that efficiently reduce the nitro groups. Many techniques such as XRD, IR, TEM and UV-Visible absorption spectroscopy have been used. TEM shows the formation of nanonickel clusters on TiO2. IR analysis confirms the appearance of the characteristic peaks of only ortho or para aminophenols. The kinetics of reduction reaction was studied. Catalyst recovery and factors affecting the reduction reaction such as phenol concentration, pH, catalyst loading and temperature have been studied. The obtained data and kinetic results show that the conversion percentage reaches 100% within few minutes. The results indicate that the nanonickel loaded over rutile or anatase TiO2 exhibit nearly the same catalytic activity in reduction of nitrophenols but more active than nanonickel in zeolite catalyst.
https://ejchem.journals.ekb.eg/article_1379_01c7cd3086cfa4e5bb5674ef03a5dae8.pdf
Nickel nanocatalyst
Rutile
anatase
Nitrophenols
Aminophenols and Reduction
eng
National Information and Documentation Centre (NIDOC), Academy of Scientific Research and Technology, ASRT
Egyptian Journal of Chemistry
0449-2285
2357-0245
2011-02-28
54
1
69
79
10.21608/ejchem.2011.1380
1380
1.4-Arylation of β-(4-acetylaminobenzoyl)acrylic Acid with Activated Aromatic Hydrocarbons under Friedel-Crafts Conditions and Some Studies with the Products
THE BEHAVIUOR of 3-(4-acetylaminobenzoyl) prop-2-enoic acid 1 with m-xylene and\or p-xylene under Friedel-Craft,s reaction conditions yielded 2- ( 2,4-Dimethyl and/or 2,5-dimethyl ) phenyl-3-(4-acetylaminobenzoyl)propanoic acids (2a,b) and thia-Micheal of acid 1 afforded 2- phenyl sulfanyl-3-(4-acetylamino benzoyl propanoic acid (3). Interaction of acids 2,3 with N2H4 , AC2O, NH2OH.HCl and PhNHNH2, yielded pyridazinone 4 , Furanone 5 1, 2oxazine 6 and 2-phenyl pyridazinone derivatives, respectively. Treatment of pyridazinone 4 with different interesting alkyl halides afforded the pyridazine derivatives 8 .
https://ejchem.journals.ekb.eg/article_1380_b3fd68176806f90992aae34bd4ab468d.pdf
3-Aroyl prop-2-enoic acid. Pyridazinone. Furanone
oxazinone and Alkyl pyridazine
eng
National Information and Documentation Centre (NIDOC), Academy of Scientific Research and Technology, ASRT
Egyptian Journal of Chemistry
0449-2285
2357-0245
2011-02-28
54
1
81
97
10.21608/ejchem.2011.1381
1381
Development and Crystallization Study of Li2O-B2O3-SiO2 Glass Ceramic Rich with ZrO2
GLASS ceramic in the system Li2O-B2O3-SiO2 was prepared by adding different amounts of ZrO2 up to maximum saturation. DTA, XRD and SEM were used to study the crystallization behavior of these glass samples. Tetragonal and monoclinic zirconia, are the only crystallized phases obtained after different heat treatment schedules. Fraction of transformed ZrO2 and total intensity of ZrO2 were calculated. Microhardness was measured for different samples, and it was found to be depending on the amount of ZrO2 added and the heat treatment parameters. Sample contains 20 g ZrO2 and treated at 650ºC for 10 hr showed higher microhardness value (14.99GPa).
https://ejchem.journals.ekb.eg/article_1381_3d45d75db314ad1e24fa32b164005fe6.pdf
hardness
Glass-ceramic
Borosilicate
Zirconia and Martensitic transformation
eng
National Information and Documentation Centre (NIDOC), Academy of Scientific Research and Technology, ASRT
Egyptian Journal of Chemistry
0449-2285
2357-0245
2011-02-28
54
1
99
113
10.21608/ejchem.2011.1382
1382
Chemical Constituents, Antischistosomal and Antioxidant Activities of the Methanolic Extract of Azadirachta indica
THE PRESENT study was performed to evaluate the in vitro …….. schistosomicidal effect of 70% methanolic extract of the leaves of Azadirachta indica and its derived ethyl acetate and n-butanol fractions against adult Schistosoma mansoni worms. Also, antioxidant properties of these extracts were determined. Owing to the high antischistosomal and antioxidant activities of EtOAc and n-BuOH fractions, they were subjected to chromatographic isolation using different chromatographic techniques. Two flavonoid compounds; (1,2) were isolated from EtOAc fraction whereas one flavonoid; (3) quercetin-3-O-α-L-rhamnopyranoside and two bidesmosidic saponins; (4,5) were isolated from the butanolic fraction. Their structures were established using spectroscopic methods. Compounds 1-3 showed high antioxidant activity whereas compounds 4 and 5 were inactive. It is the first time that antischistosomal activity of A.indica and isolation of compounds 2- 5 from this plant were carried out.
https://ejchem.journals.ekb.eg/article_1382_5d3502d1092699094fe06d75fb958796.pdf
Azadirachta indica
DPPH scavenging activity
Antischistosomal
Flavonoids and Triterpenoid saponins
eng
National Information and Documentation Centre (NIDOC), Academy of Scientific Research and Technology, ASRT
Egyptian Journal of Chemistry
0449-2285
2357-0245
2011-02-28
54
1
115
128
10.21608/ejchem.2011.1383
1383
Characterizations and Ion Exchange Behavior of A New Organic-inorganic Hybrid Cation-exchanger: Polyacrylamide Ferric Antimonate
THE POSSIBILITY to reduce the levels of heavy metals from ……aqueous waste solutions by using polyacrylamide ferric antimonate ion-exchangers has been investigated in this study. These composite ion exchangers have high chemical stability and high loading capacity. The materials were characterized using X-ray diffraction analysis, infrared spectroscopy and thermogravemetric and differential thermal analysis. The distribution coefficients and separation factors of prepared materials were calculated for Fe (III), Pb (II), Cd (II), Cu (II), and Zn (II) ions. The samples prepared show high chemical stability in water, nitric and hydrochloric acids, as well as in potassium and sodium hydroxides. All these results support the suitability of the prepared material for removals of heavy metals from aqueous waste solutions.
https://ejchem.journals.ekb.eg/article_1383_012a6333a5709c78c99b3200163561f2.pdf
Characterization
Organic-inorganic hybrid and Distribution studies
eng
National Information and Documentation Centre (NIDOC), Academy of Scientific Research and Technology, ASRT
Egyptian Journal of Chemistry
0449-2285
2357-0245
2011-02-28
54
1
129
139
10.21608/ejchem.2011.1384
1384
Synthesis and Biological Evaluation of Some New Naphthyl Derivatives as Anti-microbial Activity
IN CONECTION with our previous interest in developing new .....approaches for synthesis of heterocyclic utilizing readily obtainable starting materials, we reported here synthesis of a new heterocyclic utilizing 1-acetyl naphthalene. Reaction of acetyl naphthaline with phenyl hydrazine, thiosemicarbazide and hydroxylamine was carried out to give compounds 1,2,5, respectively. Under claisen condensation acetyl naphthalene reacted with ethylacetoacetate to give acetonaphthoyl keton 3 which converted to pyrazoline derivative 4 by reaction with hydrazine hydrate. On the other hand when acetyl naphthalene reacted with 4-chloro benzaldhyde afforded the chalcone derivative 7, which reacted with hydroxylamine, bromine, hydrazine hydrate and hydrogen peroxide a to give compounds 8, 9, 10, 11, respectively . The newly synthesized compounds were tasted as anti-microbial activity .
https://ejchem.journals.ekb.eg/article_1384_e93efb68420791e640915e053e23dbdc.pdf
eng
National Information and Documentation Centre (NIDOC), Academy of Scientific Research and Technology, ASRT
Egyptian Journal of Chemistry
0449-2285
2357-0245
2011-02-28
54
1
141
154
10.21608/ejchem.2011.1385
1385
Synthesis of A New Series of N-Substituted-3-Indolyl-Heterocycles for Antimicrobial Evaluation
CLAISEN-SCHMIDT reaction of N-ethyl (1a), N-benzyl (1b), N- .......benzoyl (1c), N-methylsulphonyl (1d) and N-benzenesulphonyl-3-acetylindoles (1e) with benzaldehyde gave 1-(N-substituted-1H-indol-3-yl)-3-phenyl-prop-2-ene-1-ones(2a-e). Cyclocondensation of 2a-e with urea, thiourea or guanidine led to the formation of pyrimidine derivatives 3a-e -5a-e, respectively. Base catalyzed reaction of 2a-e with ethyl acetoacetate gave cyclohexanone derivatives 6a-e, which were reacted with hydrazine hydrate to afford the indazole derivatives 7a-e. On the other hand, reaction of 2a-c with some hydrazine derivatives namely, hydrazine hydrate, acetyl hydrazine, phenyl hydrazine and benzyl hydrazine hydrochloride yielded the pyrazole derivatives 8a-c–11a-c, respectively. Moreover, reaction of 2a-c with hydroxyl amine hydrochloride gave the isoxazole derivatives 12a-c. The newly synthesized compounds were tested for their antimicrobial activity and the results revealed that, 4-(N-benzyl-1H-indol-3-yl)-6-phenyl-pyrimidin-2-amine (5b) showed potent growth inhibition activity at a concentration of 20 and 10 μg against Candida albicans (ATCC 10231) compared to reference drug cycloheximide.
https://ejchem.journals.ekb.eg/article_1385_6afd664e1279529405dafda4425eedf5.pdf
Claisen-Schmidt reaction
3-Acetylindoles
Pyrimidine
pyrazole
Isoxazole and antimicrobial activity